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Conversely, following necroptotic stimuli, RIPK3 activates several metabolic regulatory enzymes, thereby increasing energy metabolism and ROS, which in turn further enhance necroptosis activation (Zhang et al., 2009)

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Arch Intern Med 172(15):11801182, 22688574, doi: 10.1001/archinternmed.2012.2171

In view of the above, if a way could be found to elevate circulating and intracellular levels of glutathione, this would offer an interventional approach to overcome disease-mediated deficiencies in intracellular glutathione levels