Tirzepatide is a dual glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist
Skipping meals makes it harder to meet your daily protein goals (100-120g) and can lead to muscle loss during weight loss
Additionally, the N-terminal extension may partially shield protease-sensitive sites on the IGF-1 backbone from insulin-degrading enzyme (IDE) and other endopeptidases
Furthermore, GLP-1 augments mitochondrial efficacy, as manifested by the ameliorated oxidative metabolism of muscle tissue
GLP-1 slows your digestion, which keeps your blood sugar level and makes you feel full
Human data show thyroid problems are rare, so routine testing is not standard unless there are specific symptoms, a palpable nodule, or other clinical concern