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Deficiency of vitamin B 12 , though often undiagnosed, may affect a significant number of people, especially older adults (see the separate article on Vitamin B 12 )

Vitamin B12 injections should be used in accordance with professional guidance

In the brain, semaglutide acts on appetite centers to: Reduce hunger Slow eating Increase feelings of fullness It also delays gastric emptying so food stays in the stomach longer, which helps reduce meal size

[54] [55] Bariatric surgery commonly achieves approximately 25%-30% total body weight loss at 12 months, with durable results in many patients at 5 years or longer