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Saroglitazar, a dual PPAR / agonist currently used in India for treatment of diabetic dyslipidemia has shown promising effects in experimental models of NASH [64] and seems also to be effective in humans, reducing serum aminotransferase levels and liver size assessed by ultrasound in NASH patients after a 24-week course [65]
It is not a drug, food, supplement, or cosmetic, is not approved by the FDA, and is not intended to diagnose, treat, cure, or prevent any disease, or for human or veterinary consumption
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The gray-market demand increased after 2023, when the FDA banned compounding pharmacies from producing many of these peptides due to safety concerns, including the risk that peptides may clump together and cause the immune system to react in unpredictable ways
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The team performed liquid chromatography-tandem mass spectrometry (LC-MS/MS) to monitor metabolic and lipidomic changes following retatrutide therapy
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