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Upon activation, phosphorylated MLKL (p-MLKL) oligomerizes and translocates to the cell membrane, forming pores that disrupt electrochemical gradients, resulting in lytic cell rupture and the release of damage-associated molecular patterns (DAMPs), inflammatory cytokines and chemokines
Chen R, Li L, Zhao W
That takes place in the liver in two phases
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Consequentially, delicate interactions among amino acids are altered