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N Engl J Med 375 , 18341844 (2016)

Rare serious events include pancreatitis, gallbladder disease, and acute kidney injury in the context of dehydration

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Co-administration of ghrelin together with IgG from obese patients and ob/ob mice increased food intake in mice, which might be due to the inhibited ghrelin degradation induced by ghrelin-reactive IgG [183]