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Activating the H1 receptors causes allergy -type symptoms such as itching, swelling, vasodilation , nasal congestion, and skin reactions

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Compare the mechanism to GLP-1 peptides like semaglutide, which activate only one receptor pathway

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However, owing to concerns about off-target effects and the risk of thrombocytopenia, caution is needed when this therapy is prescribed

J Clin Pharmacol