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Pancreatitis: While rare, pancreatitis is a potential side effect of GLP-1 receptor agonists

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Hyperinsulinemia induces insulin resistance in dorsal root ganglion neurons

More serious but less common adverse effects include pancreatitis, gallbladder disease, and acute kidney injury associated with severe gastrointestinal adverse effects and dehydration

Intramuscular injections provide slightly lower bioavailability but still bypass digestive system limitations, with absorption occurring through muscle tissue into the bloodstream over several hours

Kim J, Parish AL