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Pros of GLP-1s: Non-surgical option Can lead to 1520% body weight loss in clinical trials May improve blood sugar, cholesterol, and inflammation Weekly injections, often self-administered Cons of GLP-1s: Real-world weight loss may be lower than clinical trials (510%) Side effects include nausea, vomiting, fatigue, and gastroparesis High cost and limited insurance coverage Weight may return if medication is stopped What is weight loss surgery
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In a phase 2 trial published in The New England Journal of Medicine , retatrutide produced substantial, dose-dependent weight reduction in adults with obesity over 48 weeks
Table 4 Studies on natural products showed a beneficial effect on gut microbiota, liver, and hypothalamus
This is the first sign that the GLP-1 receptors in the gut and brain are being activated
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