Holotranscobalamin (active B12) where available, this is a more sensitive early marker of B12 depletion and may be preferred in some settings [12] [15] Full blood count to identify macrocytosis or anaemia Folate levels as folate deficiency can co-exist and confound the clinical picture Methylmalonic acid (MMA) and homocysteine functional markers of B12 status, useful when serum B12 is borderline
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In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining