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Table of Contents The Trial and What It Measured How Endogenous Hormone Release Differs from Synthetic GLP-1 Drugs How the Extract Spared Muscle While Cutting Fat Tolerability and Side Effects The Research Gap the Study Fills Behavioral Changes and Reduced Food Intake Closing Thoughts The Trial and What It Measured A six-month clinical trial reports that a gut-targeted bitter hop extract, marketed as a natural GLP-1 supplement and the active ingredient in Calocurb , produced more fat loss than a placebo while participants estimated muscle mass held steady

(PubMed) Clark WM, Wechsler LR, Sabounjian LA, Schwiderski UE, Citicoline Stroke Study Group

Consequently, researchers observe a significantly extended half-life (estimated between 20 to 30 hours) and substantially increased biological potency in vitro

However, if you have a sensitive stomach, taking it with a small snack is perfectly fine and likely won't significantly hinder the benefits of a liposomal formula

[8][9] A baseline is still smart if you have liver history or take liver-metabolized meds

Kumar GP, Khanum F (2012) Neuroprotective Potential of Phytochemicals