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Acknowledgements We thank Dr Robert Lefkowitz for insightful and helpful discussion
as a probe of the D-Phe stereocentre, the single inversion that both stabilises the bioactive turn of the His-Phe-Arg-Trp core and removes a favoured chymotrypsin-like cleavage point
Mounjaro is sold in pens containing 2.5mg, 5mg, 7.5mg, 10mg, 12.5mg, and 15mg doses
Fridolf T, Ahrn B (1991) GLP-1(736)amide-stimulated insulin secretion in rat islets is sodium-dependent
Body weight reduction in obesity has been characterised across the SURMOUNT program
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