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Its therapeutic effects are attributed to multiple mechanisms, including upregulation of the renoprotective Klotho protein, suppression of proinflammatory cytokines, attenuation of tissue fibrosis, and reduction of proteinuria (188)

Alcohol and the cardiovascular system: research challenges and opportunities

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Bellamy MF, McDowell IFW, Ramsey MW, Brownlee M, Bones C, Newcombe RG, and Lewis MJ (1998)

Therefore, the existing safety evidence is insufficient to support pharmaceutical approval

During the process of research & development, imipramine was synthesized as a structural analog of chlorpromazine