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Administering two doses in close succession, by contrast, stacks a full dose onto substantial residual drug and produces a transient exposure peak above anything the weekly schedule generates at an agent whose principal dose-limiting effect is nausea
Future Research Directions and Unanswered Questions Despite 50+ years since Pickarts initial isolation work, significant mechanistic and clinical questions remain: Receptor identity: GHK-Cus gene regulatory effects are well-documented, but the specific cellular receptors mediating them remain incompletely characterized
J.BrzozowskiT
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PMID 28861405
A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse)
