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Moreover, enzymes (alcohol dehydrogenase 1, aldehyde dehydrogenase 2, and cytochrome P450 2E1) and regulators (farnesoid X receptor) involved in alcohol metabolism were markedly increased in APP/PS1 mice treated with alcohol compared to WT controls, indicating dysregulated alcohol metabolism

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Schiering C, Wincent E, Metidji A, Iseppon A, Li Y, Potocnik AJ, et al