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doi: 10.1155/2019/2716870 10 Kheiri ManjiliHSharafiAAttariEDanafarH

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Balancing the structural robustness required to prevent premature drug leakage in systemic circulation with the necessity for stimuli-responsive disassembly at the tumor site remains a critical engineering challenge

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Overall, we found that CAR T cells in post-infusion BM samples from LTR have high levels of mTOR signaling, high metabolic polyfunctionality, and an effector immunometabolic profile, and that the BM microenvironmental milieu of LTR may promote mTOR activity for improved anti-tumor activity

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