Elevated circulating BCAAs have been observed in both human and mouse models of pancreatic cancer in the early stages of progression, and blood BCAAs levels rise due to excessive protein breakdown in the tissues surrounding pancreatic cancer
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NyarkoSHGreenbergLTSaadeGRPhibbsCSBuzasJSLorchSAet al
These reports are intriguing and deserve further scientific exploration to understand potential mechanisms, such as the modification of gut microbiota or inflammation pathways
As emerging therapies, applications of probiotics/prebiotics could offer new perspectives and promising avenue to improve the prevention and treatment of precancerous lesions, providing patients with more precise and personalized treatment options
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