Several lines of evidence support the pivotal role of the oxidized cellular state in retinal cell damage [39, 40]
The interactions between citrulline and molecules associated with the JAK/STAT axis, together with the regulatory effects of urea cycle-related enzymes on the activation of inflammatory macrophages, suggest that the iNOS/NO axis may exert feedback regulation on pro-inflammatory signaling in different contexts ( At the intervention level, regulating the metabolic partitioning of Arg can alter macrophage phenotypes and inflammatory intensity
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Across published trials and case series, the most frequent reported events are injection-site reactions (redness, induration, transient discomfort), headache, mild nausea, and temporary fatigue
Cluster-based marker identification and differential expression were performed using Seurats FindMarkers/DESeq2 with logfc.threshold = 0.2 comparing specific groups (i.e
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