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They are associated with poor prognosis and are the leading cause of mortality in NF1 patients

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Additionally, GLP-1R signaling in -cells activates mTOR-dependent transcription of hypoxia-inducible factor 1 alpha (HIF-1), which upregulates glucose expression and promotes glucose metabolism [8, 9]

According to the position of the treated teeth, the anterior teeth and anterior molars are classified as single-root teeth, while the molars are classified as multiple-root teeth