If the math is wrong, it gets caught before the vial is touched
doi: 10.1038/s41586-023-05940-w
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The balance between these two pathways could determine whether paracetamol exposure in the first or third trimester increased the predisposition to subsequent asthma, through the build-up of toxic oxidative metabolites
46 Moreover, the higher GSH level and unstable redox state of cancer cells 6 were utilized by the materials to initiate Fenton-type reaction, causing severe oxidative stress and irreversible damage
We take the K m of GST for GSH to be 5200 M, midway between the values 4500[21] and 5600[22], K m = 15 M for NAPQI, and V max = 72,000 M/hr