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Li Y, Li S, Zhai Q, Hai J, Wang D, Cao M, et al
J Clin Endocrinol Metab 2008;93(7):2800-2805
Cagrilintide, with six amino acid substitutions in human amylin and a dual carboxylic fatty acid chain similar to semaglutide attached to the first amino acid, lysine, exhibits an extended half-life, allowing for a once-weekly subcutaneous administration regimen [97,98]
This deficiency restricts tissue uptake, leading to decreased accumulation in the heart and skeletal muscle and potentiates increased renal carnitine loss [21, 22] leading to systemic carnitine depletion [23]
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