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A 2019 systematic review by Dilokthornsakul and colleagues in the Journal of Cosmetic Dermatology searched five databases through October 2017 and included four clinical studies (three placebo-controlled RCTs and one single-arm trial) evaluating oral glutathione 250-500 mg/day and topical 2% oxidized glutathione, concluding that evidence for skin-whitening effects remained inconclusive due to inconsistent findings across trials and the limited bioavailability of oral GSH with no significant effect observed in sun-protected skin areas

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Potential Limitations and Cautions While AOD 9604s prospects seem promising, its pivotal to acknowledge potential limitations: Data on long-term safety is still in the nascent stages

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Patients experience abdominal pain, diarrhea, weight loss, fatigue, and potential complications including strictures, fistulas, and abscesses