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There are different kinds of SOD, depending on the metal that acts like a co-factor in its catalytic site, but all of them act basically according to the same reaction described by McCord and Fridovich in 1969: 1.14.4.1.1 SUPEROXIDE DISMUTASE COPPER-ZINC DEPENDENT The form that contains copper and zinc, called superoxide dismutase copper-zinc dependent (CuZnSOD), is very stable and seems to be present in practically all the eukaryotic cells (plants or animals)

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doi: 10.3949/ccjm.76a.08070, 48

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It penetrates the outer skin layers and acts locally on skin cells, fibroblasts, and the extracellular matrix