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Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes (Rosenstock J et al.)
It acts on the hypothalamic thermoregulatory center, inhibiting the synthesis of prostaglandins and the effects of endogenous pyrogen, leading to peripheral vasodilation, increased blood flow to the skin and increased sweating, which contribute to heat loss
Patients taking medications with a narrow therapeutic index, including some antiseizure medications, should be monitored closely, as delayed gastric emptying from GLP-1 receptor agonists may affect drug absorption
Semaglutide changes the conversation your body is having with itself
42 However, results from the SURMOUNT trial, a phase III RCT of tirzepatide, demonstrated that lean-mass reduction is approximately three times less than fat-mass reduction, contributing to an overall improvement in body composition
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Passaia, G., Queval, G., Bai, J., Margis-Pinheiro, M
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