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Despite the availability of pharmacological treatments, these interventions fail to prevent disease progression due to their limited ability to penetrate the blood-brain barrier (BBB) and systemic side effects

Topical capsaicin Capsaicin is an alkaloid extracted from red chili peppers and reduces painful stimuli to the CNS by removing substance P from vanilloid nerve receptors [72]

Glutathione runs faster, about 15 minutes

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Given that alcohol and drug abuse activate the same reward pathways involved in food intake, it is plausible that appetite-regulating peptides, such as GLP-1, exert their effects on brain regions associated with reward and addiction [20, 21]