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Although preclinical data are promising, we point out that insulin regulation and the metabolic response to a certain diet often differ between mice and humans

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2, we integrate the multilayered regulatory network governing GDF15 expression under cellular stress conditions, including core mechanisms of transcriptional activation, signaling pathway crosstalk, epigenetic modification, and posttranscriptional regulation

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Cytom Part A 83A(5):483494 Foukas LC, Berenjeno IM, Gray A, Khwaja A, Vanhaesebroeck B (2010) Activity of any class IA PI3K isoform can sustain cell proliferation and survival