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Pharmaceutical companies have invested billions developing advanced transdermal technologies (iontophoresis, sonophoresis, chemical enhancers, microneedles) specifically because passive patches cannot deliver most drugs
The ongoing SURPASS-CVOT and SYNCHRONIZE-CVOT trials will expand this landscape, testing the cardiovascular efficacy of dual agonists like tirzepatide and survodutide in broader populations, including those with obesity and established cardiovascular risk (ClinicalTrials.gov identifiers: NCT04255433, NCT05556512)
The exact dose depends on your weight, comorbidities, kidney function, and disease activity, and should always be determined by your prescribing physician
It might just become your new fave
From nausea to diarrhea, taking Wegovy ( semaglutide ) comes with a list of potential side effects that can be uncomfortable, frustrating, and, sometimes, a bit gross
In tandem, the arcuate nucleus of the hypothalamus, which contains both anorexigenic proopiomelanocortin-expressing neurons and orexigenic agouti-related protein/neuropeptide Y-co-expressing neurons, has a key role in the homeostatic control of food intake 4
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