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While SSRIs have been associated with improved subjective sleep in clinically depressed patients, their effects on sleep in the general population are not well studied

A meta-analysis also reported diagnoses of medullary thyroid carcinoma in patients taking GLP-1RAs, reinforcing the at-risk status as a contraindication to GLP-1RA treatment

secondary outcomes included changes in metabolic parameters including lipids, waist circumference, resting energy expenditure, and response to a meal tolerance test

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A further impact is that if the prices of other drugs outstrip inflation, companies will be liable to pay rebates