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Mood or mental health changes: Because Contrave affects brain chemistry, it can sometimes trigger mood swings, anxiety, orrarelymanic or depressive episodes

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Exenatide induces an increase in vasodilatory and a decrease in vasoconstrictive mediators

At the same time, concurrent GLP-1 and GIP activity may help offset the glucose-raising effects associated with glucagon alone.[1][3] Ongoing Phase 3 research will help clarify how this combined mechanism translates into clinical outcomes