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The expression of succinate dehydrogenase isoforms SDHC and SDHD was reduced by IC-B in ABMR while SDHA and SDHB were lowered by PEC in complex II, the second entrance into the ETC ( Figure 4E )

In the SN neurons of PD, the expression of Nrf2 in the nucleus is enhanced, and the expression of its signature proteins NQO1 and HO-1 is upregulated, suggesting a brain protective effect mediated by Nrf2

B12 replacement produces the clearest results in people whose levels are low