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Therefore, DPP-4 inhibitors extend the half-life of endogenous GLP-1 lead to a 2threefold elevation of endogenous GLP-1 concentration, and provide beneficial effects in T2DM [110, 111]

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Receptor activation In spite of various conformational changes upon ligand binding, signaling initiation by either peptidic or small molecule agonists shares a common pathway, i.e ., reorganization of the central polar network, HETX motif and TM2-6-7-helix 8 polar network, as well as the hallmark outward movement of TM6 (ref

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