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Additional receptor destinations involve retrograde transport towards the Golgi apparatus ( Evidence from primary mouse islets and clonal beta cells (INS-1 832/3) shows that Exenatide causes a greater amount of GLP-1R degradation compared to endogenous GLP-1, with this effect apparently due to differences in the susceptibility of the agonists for degradation by the endopeptidase endothelin converting enzyme 1 (ECE1) (Metzler et al., 2001) is associated with the control of GLP-1R function
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After adjustment for sex, age, baseline body mass index, and hepatic steatosis using ANCOVA, weight loss remained significantly different across treatment groups (F = 12.960, p = 0.001) (Table 4)
10.1089/dna.2018.4308 DNA Cell Biol
Richard D, Picard F, Lemieux C, Lalonde J, Samson P, Deshaies Y