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Mytesi is a plant-based oral drug already approved for HIV-related diarrhea that has shown additional benefits for abdominal pain, discomfort, bloating and constipation when studied in HIV, irritable bowel syndrome (IBS) and cancer therapy-related diarrhea

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The results have been consistently promising across multiple tissue types and organ systems, though large-scale human clinical trials remain limited

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Eligibility under TA875 generally requires a BMI of 35 kg/m or above (or 3034.9 kg/m in certain higher-risk groups) alongside at least one weight-related comorbidity, and treatment is currently recommended for up to two years within a specialist service

GLP-1 receptor agonists like semaglutide take the spotlight, enhancing insulin secretion in response to elevated blood sugar levels