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Specifically, rodent studies showed an increased incidence of thyroid C-cell tumours (medullary thyroid carcinoma) when exposed to GLP-1 receptor agonists at doses significantly higher than those used therapeutically in humans

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This state-of-the-art narrative review synthesizes current evidence from clinical trials, pharmacovigilance databases, and real-world cohorts to provide a comprehensive evaluation of the safety and tolerability of GLP-1RAs and tirzepatide

However, current evidence suggests that the development of such antibodies does not significantly reduce the drugs effectiveness or cause any distinct adverse reaction profile

We hypothesize that after delivery into the biofilm-infected sites, SeC@PA can not only deplete GSH and generate reactive nitrogen species (RNS) to enhance the anti-biofilms effect of PDT, but also utilize the high levels of GSH in biofilms to generate hydroxyl radical (OH) through a series of catalytic cascade reactions (Fig

The design and conduct of the study was approved by the ethical committee of Xinjiang Medical School