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Transdermal delivery, favoured for its active and passive approaches and advantages over topical delivery, has been extensively studied and employed for therapeutics

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Most patients on this pathway: Have tried and failed to get insurance coverage Have no private insurance Earn too much to qualify for patient assistance but not enough to afford it comfortably View it as a time-limited intervention (6 to 12 months) rather than indefinite treatment The financial sustainability question is real

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Such heterogeneity among studies impedes cross-comparison and prevents the development of evidence-based therapeutic protocols

R., & Cacciola, F