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In the SURMOUNT-1 obesity trial, tirzepatide produced mean weight reductions of roughly 1521% depending on dose over 72 weeks ( Jastreboff et al., NEJM 2022
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PMID: 42176271 Cell Rep 2024 Aug 7;43(8):114591
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2024;326:C136783
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The trial met its primary endpoint, showing a biopsy-proven improvement in MASH after 48 weeks, without worsening of fibrosis stages F1, F2 and F3 (mild to moderate or advanced scarring)
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Oxidative cell death in cancer: mechanisms and therapeutic opportunities, Cell Death & Disease 2024 15:8 , vol
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These medications have been studied in human clinical trials and shown to support: - Weight loss - Heart protection - Kidney protection - Liver disease What Are the Side Effects of GLP-1 Medications
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