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For Canadians, the takeaway is clear: affordable GLP-1 access is coming, but we're not there yet

IV is preferred due to variable oral bioavailability (discussed further below)

GLP-1 Receptor Response: When semaglutide is injected into the body, it activates GLP-1 receptors in releasing insulin (which stops glucagon production) helping manage healthy blood sugar levels and weight

In contrast, semaglutide is a selective GLP-1 receptor agonist that only targets the GLP-1 receptor

Mar 2008;20(3):185-196

In animal experiments on such drugs, studies on rodents have found that the GLP-1RAs may promote the development of medullary thyroid carcinoma, but this effect has not been observed in non-human primates [23]