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While chronic hypoxia drives long-term metabolic reprogramming and stable epigenetic alterations ( 2.2 Hypoxia-inducible factors Hypoxia-inducible factors (HIFs) are central regulators of the cellular response to low oxygen tension and play a pivotal role in mediating the adaptive changes observed in hypoxic tumors ( Figure 4 ) ( Figure 5 ), HIF-1 is continuously synthesized but rapidly degraded through the oxygen-dependent activity of prolyl hydroxylase domain (PHD) enzymes, which hydroxylate specific proline residues (Pro-564 and Pro-402) within the oxygen-dependent degradation domain (ODD) of the HIF-1 subunit
* Correspondence: Limin Zheng, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
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Accessed 8 Aug 2023
Tyrrell RM, Pidoux M
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