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221 Furthermore, PTBP1 hyperlactylation in GSCs promotes glioma progression and supports the maintenance of GSCs by inhibiting its interaction with TRIM21 and enhancing its RNA-binding affinity and stabilizing PFKFB4 mRNA, which in turn accelerates glycolysis, eventually forming a feedback loop that exacerbates tumorigenesis
investigators considered them unrelated, but no long-term oncology safety data exists)
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