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In addition, the difference of drug administration methods such as oral gavage or mixed in the meal might have strongly affected the results as it is known that drug turnover such as metabolism and excretion is quite fast especially in rodents
MI: GLP-1 RAs showed a trend toward a reduced risk of myocardial infarction (MI), including acute subtypes
In a phase 2b trial, tirzepatide treatment was associated in a dose-dependent manner with decreased levels of apolipoprotein (apo) B, apoC-III, large triglyceride-rich lipoprotein particles, and small low-density lipoprotein particles, suggesting a shift towards a less atherogenic lipoprotein profile [77]
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Bioinformatics 29(10):13171324
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