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Phase 2 results announced last November showed weight loss of up to 20.1%, along with improvements in body mass index, waist circumference, blood pressure and blood glucose levels.

Thus, ADT is the frontline treatment and directed toward disruption of T-DHT-AR axis by suppression of gonadal T by medical or surgical castration ( de novo steroidogenesis, which involves upregulation of enzymes required for stepwise synthesis from cholesterol to T and DHT (111)

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