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4.1
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Description

For patients who have been managing that cost out-of-pocket, the arrival of a generic represents a meaningful change

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"Adverse drug reactions"

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Jan 2021;38(1):101-123

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This is a decision to make with your oncology team rather than on your own

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Tesamorelin, a synthetic GHRH analog, that stimulates the synthesis and release of endogenous GH, is the first and, so far, only treatment indicated for the reduction of excess abdominal fat in HIV lipodystrophy (144)

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Complex formulations that are difficult to replicate controlled-release systems, transdermal patches, sterile injectables can delay generic entry by 12 to 24 months beyond compound patent expiry, because generic companies need time to demonstrate bioequivalence through clinical studies

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