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doi: 10.1016/j.ctim.2019.102273 59

Together, these findings suggest that X(PC) triggers a caspase-1-dependent lytic cascade, but that this pathway is only partially sensitive to QVD inhibition likely due to the threshold-like nature of pyroptotic signaling, and that off-target cleavage of proteins such as the substrates uncovered during profiling contributes to this complex, PANoptotic-like cell death

The analysis revealed that L-carnitine supplementation has potential antihyperlipidemic effects, as it reduces TC, TG, and LDL-C levels while improving HDL-C levels