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Goldsmith concedes that many recent studies of HCG that support the diet regimen do not meet the high standards of the scientific community

The absence of manufacturing oversight increases exposure to compounds of unverified quality

These symptoms often result from an imbalance in the gut microbiome, inflammation, and oxidative stress

While hydroxyl radicals induce mitochondrial oxidative stress, the reactive copper intermediates covalently bind to DLAT, triggering its aggregation and thereby initiating cuproptosis

For example, concurrent use with corticosteroids may amplify the potential for fluid retention or electrolyte imbalance, particularly sodium and water retention

Potentially greater weight loss compared to monotherapy