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They also established that overexpression of GPX4 or knock down of STUB1, a GPX4 E3-ligase, alleviated imatinib-mediated ferroptosis induction

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Other than a prior study showing that psychological stress increased striatal DA release in the human ventral striatum [64], our findings are the first to document in humans that a drug-induced aversive and stressful state was associated with DA increases in the dorsal striatum

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(2019a)

It means the agency no longer has an active nomination designating dihexa as posing "significant safety concerns." That happened because the original nominator voluntarily withdrew their petition