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Pocket 3, for example, is formed jointly by SKP2 and CKS1, which is essential for p27 binding and ubiquitination by SKP2 (Figure 2A)
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J Biol Chem (2001) 276:3200815.10.1074/jbc.M104794200 36 KobayashiEHSuzukiTFunayamaRNagashimaTHayashiMSekineHet alNrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription
10.1016/j.bbrep.2023.101578 173
Herniated discs cause the majority of cases
Together, these results demonstrate that reprogramming BoNT/X protease to cleave gasdermin D is achievable through iterative substrate design, negative selection and circuit optimization
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