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Patients with recurrent vulvovaginal candidiasis (four or more episodes annually) require more intensive treatment: an induction phase with fluconazole 150 mg every 72 hours for 2-3 doses or 10-14 days of topical therapy, followed by maintenance therapy with fluconazole 100-200 mg weekly for 6 months

This traditional distribution method remains the primary means by which the drug reaches the majority of patients

2014 (PMID 25331030, NCT00672074) Phase 2 trial reported numerical but not statistically significant reduction in time to first bowel movement

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