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Chan ATC, et al

L-carnitine, TMAO, and CVD While research has found associations between increased circulating levels of L-carnitine and increased risk of atherosclerosis and CVD, the real concern may be how carnitine is metabolized

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GLP-1 receptor agonists e.g., semaglutide, liraglutide commonly cause gastrointestinal adverse effects such as nausea, vomiting, diarrhea, constipation, and abdominal discomfort, especially during dose escalation, less common risks include pancreatitis, gallbladder disease, and hypoglycemia mainly with insulin sulfonylureas

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In addition, supplementing the raw materials (cysteine, glycine, glutamate, and selenium) for synthesizing GSH or GPX to achieve an elevated GSH system in the myocardium is another feasible strategy