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Using the same spot repeatedly can lead to lipohypertrophy, which are fatty lumps under the skin that interfere with how well your body absorbs the medication

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Caroline Apovian, a professor of medicine at Harvard Medical School and co-director of a weight-loss center at Brigham & Women's Hospital in Boston, told WSJ that Ozempic may trigger strange dreams because it promotes the production of a gut hormone that has receptors in the brain

Buckley ST, Bkdal TA, Vegge A et al (2018) Transcellular stomach absorption of a derivatized glucagon-like peptide-1 receptor agonist

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Both medication types also commonly influence appetite and weight, as they act on overlapping hormonal and reward pathways in the brain (Srinivasan et al., 2025)