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One familial risk factor is the allele of apolipoprotein E (APOE * 4) associated with Alzheimer's disease (AD) (Saunders et al., 1993)

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They found that in two key brain regions the insular cortex (which plays a role in emotions, empathy and self-awareness) and visual cortex (responsible for integrating and processing visual information) the ratio of GABA to glutamate decreased over the three-month period in the treatment group

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Duckett MM, Phung SK, Nguyen L, et al